时间:2018年11月18日 20:59:34

We asked you on Facebook. We went outside the studio (*gasp*) and asked people in the street. You tweeted us on Twitter. You told us 70 experiences every Michigander should have at least once.These are in no particular order...except to note Sleeping Bear Dunes was, hands down, the most popular response.Followed by ;hunting for Petoskey stones.;Social Media Producer Kimberly Springer spoke with Cynthia Canty about the experiences, places and events youre most excited about in our state.And dont get us wrong: there was a lot of grousing about potholes and MiDAS -- maybe rightfully so -- but we figure everyone needs a break. Time to stop and have just a little bit of gratitude for the positive things we see happening in communities around the state as we report the news and cultural happenings in Michigan.So get out your pen/stylus, check off the things youve done, and find some new experiences to have in our state.1.Sleeping Bear Dunes, especially Pierce Stocking Drive #9 stop.2.Red Pop3.Bike along a bluff overlooking Lake Michigan on M-119/ a cruise along M-119, especially north of Harbor Springs.4.Kayaking, boating, hiking at Pictured Rocks5.Camp near the Lake Michigan shore in the Nordhouse Dunes6.Sleeping Bear Dunes climb amp;amp; Petoskey stone hunting7.Sleeping Bear Dunes climb amp; Petoskey stone hunting6.Pasties7.Go on a wine tasting tour in Leelanau County8.Tube down the Platte River until you hit Lake Michigan9.Get lost in a corn maze10.Grand Rapids11.Wild blueberry picking (especially the U.P. during blueberry season)12.Tahquamenon Falls13.The Detroit Institute of Arts14.Hunting Petoskey stones15.Campus Martius Park (ice skating, concerts)16.The Keweenaw Peninsula17.The Headlands International Dark Sky Park18.Detroits Thanksgiving Day Parade (;where every race, ethnicity, gender etc. are all together and enjoying it together!;)19.;Going up North;20.A sunset from Ludington Light21.Jumping off the breakwall in Petoskey22.Isle Royale National Park23.Mackinac Bridge (driving across it, going under it on a ferry)24.A fall color tour by train25.Visiting Whitefish Point Light26.Mackinac Island (a Carriage Tour, biking to Fort Holmes)27.Any activity on the Huron River28.Tip-Up Town (Houghton Lake)29.The Cheeseburger in Caseville Fest30.Lighthouse tours31.Art Prize (Grand Rapids)32.Sunset in Grand Haven (during the spring, summer or fall!)33.A race at Michigan International Speedway34.Brockway Mountain Drive in the U.P.35.;A dune ride around Silver Lake in Mears, MI or take your own vehicle on the dunes. Either way, its beautiful there.;36.Crawling to the top of the Copper Peak ski flying jump (Ironwood, MI)37.Greek Town (Detroit)38.Gwen Frostics studio in Benzonia39.Drive old 31 from Muskegon to Hart40.Tunnel of trees starting at Harbor Springs41.Sailing Tawas Bay42.Michigan beer43.Laughing Whitefish Falls44.M-22 drive (especially in fall)45.Peterson Beach on Lake Michigan46.Whitefish bay and birding47.Jeepin Marblehead on Drummond Island48.Camping along Lake Michigan in the northern part of the state49.Detroit Jazz Festival50.The Corktown Detroit celebration held the Sunday before St. Patricks Day51.Presque Isle Lighthouse52.;The thrill of the catch! Fishing is or should be an equal mix of relaxation and exhilaration. Catch and release, if you please.;53.Touring the Sault Ste. Marie locks54.Silver Beach (St. Joseph, MI)55.See Big Mac lit up at night!56.Kitch-iti-kipi Spring at Palms Book State Park57.AuSable River Canoe Marathon (Grayling, Michigan)58.Higgins Lake59.Saugatuck60.Jumping off the Black Rocks in Marquette61.Tecumsehs River Raisin Run62.Great Lakes when theyre frozen63.McCourtie Parks beautiful cement bridges (Jerome, MI)64.Boating anywhere along Michigan shores and islands65.Yacht dreaming in Saugatuck66.Sunsets on Lake Michigan67.Hiking in the U.P.68.Ann Arbor Art Fairs69.Flint Institute of Art70....and by popular demand: Holland and the Tulip Festival!201508/394898

Scientists study chemicals for their potential to cause cancer, but usually they examine them one at a time.And yet, were exposed to mixtures of different chemicals every day.Dr. William Goodson is a senior scientist with the California Pacific Medical Center Research Institute.Hes the lead author of a new paper in the journal Carcinogenesis. He worked with a team of more than 170 scientists around the world to examine what we know about the potential for mixtures of chemicals to cause cancer.Heres an excerpt from the papers abstract:Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals.Why study mixtures?Goodson says we know very little about the mixtures of chemicals were exposed to.Up until now, he says, researchers have focused on whether or not individual chemicals can, on their own, cause cancer. There just havent been many studies on how chemicals might work together to lead to cancer.;Because its more complicated to do,; he says.;And what were realizing, and what this group spent several days talking about, was that theres reason to think that it doesnt take one chemical to take it all the way from normal to cancer.;Goodson says different chemicals, when combined, might lead to a carcinogenic mixture.;One chemical can take it part way, another chemical will take it another portion of the way and maybe a second, third, or fourth chemical will take it all the way,; he says.He says this concept is still just theoretical.;But we think it really needs to be looked at very carefully,; Goodson says.Beginning the processHe says testing mixtures of chemicals is tricky.;Probably the biggest challenge is trying to figure out which mixtures youre going to test, and that requires making some educated guesses about which ones to look at,; Goodson says.And it wont be cheap.;Its going to require a lot of effort to put this together,; he says. ;No companys going to take this on because nobody is going to make money by deciding what mixtures are unsafe. It really requires a funding effort and an organizational effort, really probably on a federal level.;He also noted that many big-name organizations fundraise for cancer research, but there are gaps in the types of research they fund.;They will talk about prevention, but if you look at their portfolio of research, almost none of them actually do anything looking at chemicals, and certainly not mixtures of chemicals,; Goodson says.201506/382367

What is metabolism really?新陈代谢是什么?Statements like “he can eat a lotbecause he has a fast metabolism” are somewhat misleading.“他很能吃是因为他新陈代谢很快”像这样的说法有点误导我们。Metabolism isnt about the digestion of food in your stomach;新陈代谢不是指食物的消化能力,its the name given to all of the chemical changes that occur in an organisms tissue cells.而是指一种在组织细胞内发生的化学变化。There are basically two kinds of chemical changes that can occur; tissue matter can be built,or it can be broken down.基本上可分为两类化学反应:合成或分解组织细胞。These processes are called anabolism and catabolism.这些过程叫作合成代谢和分解代谢。More specifically, anabolism is responsiblefor an organisms growth, its maintenance, and the repair of its tissues.具体地说,合成代谢负责有机组织的数量增长,维护和修复。So when you cut yourself and your skin scabs over and heals, youre seeing anabolism at work.所以,当皮肤割伤后会自动结疤愈合,这就是合成代谢在起作用。Or if you grow taller or wider, thats also evidence of anabolism.要建造和修复组织细胞,合成代谢需要能量和原料。In order to build tissue and repair it, however, anabolism requires energy, as well as material with which to build.或者长高长胖,那也是合成代谢。This energy and building material comes from the breaking down of larger, morecomplex material, a process called catabolism.而能量和原料就来自于分解更大,更复杂的细胞,这个过程就叫分解代谢。As well as producing energy and building material,catabolism also breaks down material for excretion from the body.与合成反应一样,分解代谢需要的能量和原料来自于身体的分泌物。Both anabolism and catabolism are necessary for survival and good health.合成和分解代谢在对于身体健康很重要。Understanding theseprocesses can help one make good decisions about exercise and diet.而了解这些过程可以帮助我们对运动和饮食做出更好的决定。For example, when anathlete trains, her muscle fibers break down.例如,运动员训练时他的肌纤维会受损。However, the daily recommended amount of proteinis all that is needed to meet the anabolic and catabolic needs of the body and thus repair musclesfibers.所以每日推荐的蛋白质就是身体合成和分解代谢所需的量,这样才能修复肌纤维。 201410/333874

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